Targeting the Dysfunctional Placenta to Improve Pregnancy Outcomes Based on Lessons Learned in Cancer

In recent decades, our understanding of the disrupted mechanisms that contribute to major obstetrical diseases, including preeclampsia, fetal growth restriction, preterm birth, and gestational diabetes, has increased exponentially. Common many these obstetric diseases is placental maldevelopment dysfunction; placenta a significant component maternal–fetal interface involved in coordinating, facilitating, regulating maternal nutrient, oxygen waste exchange, hormone cytokine production. Despite advances development function, there are currently no treatments for dysfunction. However, given transient nature accessibility from circulation, offers unique opportunity develop targeted therapeutics routine practices. Furthermore, similar developmental paradigms between cancer, an appropriate current knowledge cancer treatments. this review, we highlight similarities early introduce number therapies being explored pregnancy. We also propose new effectors research have potential be pregnancy complications. Finally, describe method targeting using nonviral polymers capable delivering plasmids, small interfering RNA, other effector nucleic acids, which could ultimately improve outcomes complicated pregnancies.